DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously

We report the development of a platform of dual targeting Fab (DutaFab) molecules, which comprise two spatially separated and independent binding sites within the human antibody CDR loops: the so-called H-side paratope encompassing HCDR1, HCDR3 and LCDR2, and the L-side paratope encompassing LCDR1,...

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Publicat a:Nat Commun
Autors principals: Beckmann, Roland, Jensen, Kristian, Fenn, Sebastian, Speck, Janina, Krause, Katrin, Meier, Anastasia, Röth, Melanie, Fauser, Sascha, Kimbung, Raymond, Logan, Derek T., Steegmaier, Martin, Kettenberger, Hubert
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7846786/
https://ncbi.nlm.nih.gov/pubmed/33514724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-20949-3
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