De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands

The aberrant gain of DNA methylation at CpG islands is frequently observed in colorectal tumours and may silence the expression of tumour suppressors such as MLH1. Current models propose that these CpG islands are targeted by de novo DNA methyltransferases in a sequence-specific manner, but this has...

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發表在:Nat Commun
Main Authors: Masalmeh, Roza H. Ali, Taglini, Francesca, Rubio-Ramon, Cristina, Musialik, Kamila I., Higham, Jonathan, Davidson-Smith, Hazel, Kafetzopoulos, Ioannis, Pawlicka, Kamila P., Finan, Hannah M., Clark, Richard, Wills, Jimi, Finch, Andrew J., Murphy, Lee, Sproul, Duncan
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2021
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7846778/
https://ncbi.nlm.nih.gov/pubmed/33514701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20716-w
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