Detection of genetic variation and base modifications at base-pair resolution on both DNA and RNA

Accurate decoding of nucleic acid variation is critical to understand the complexity and regulation of genome function. Here we use a single-molecule magnetic tweezer (MT) platform to identify sequence variation and map a range of important epigenetic base modifications with high sensitivity, specif...

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Vydáno v:Commun Biol
Hlavní autoři: Wang, Zhen, Maluenda, Jérôme, Giraut, Laurène, Vieille, Thibault, Lefevre, Andréas, Salthouse, David, Radou, Gaël, Moulinas, Rémi, Astete, Sandra, D’Avezac, Pol, Smith, Geoff, André, Charles, Allemand, Jean-François, Bensimon, David, Croquette, Vincent, Ouellet, Jimmy, Hamilton, Gordon
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7846774/
https://ncbi.nlm.nih.gov/pubmed/33514840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-01648-7
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