Microthermal-induced subcellular-targeted protein damage in cells on plasmonic nanosilver-modified surfaces evokes a two-phase HSP-p97/VCP response

Despite proteotoxic stress and heat shock being implicated in diverse pathologies, currently no methodology to inflict defined, subcellular thermal damage exists. Here, we present such a single-cell method compatible with laser-scanning microscopes, adopting the plasmon resonance principle. Dose-def...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Mistrik, Martin, Skrott, Zdenek, Muller, Petr, Panacek, Ales, Hochvaldova, Lucie, Chroma, Katarina, Buchtova, Tereza, Vandova, Veronika, Kvitek, Libor, Bartek, Jiri
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2021
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7846584/
https://ncbi.nlm.nih.gov/pubmed/33514738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-20989-9
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