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Targeting the NPL4 Adaptor of p97/VCP Segregase by Disulfiram as an Emerging Cancer Vulnerability Evokes Replication Stress and DNA Damage while Silencing the ATR Pathway

Research on repurposing the old alcohol-aversion drug disulfiram (DSF) for cancer treatment has identified inhibition of NPL4, an adaptor of the p97/VCP segregase essential for turnover of proteins involved in multiple pathways, as an unsuspected cancer cell vulnerability. While we reported that NPL...

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Publicat a:Cells
Autors principals: Majera, Dusana, Skrott, Zdenek, Chroma, Katarina, Merchut-Maya, Joanna Maria, Mistrik, Martin, Bartek, Jiri
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7072750/
https://ncbi.nlm.nih.gov/pubmed/32085572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9020469
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