Modeling the structure of the frameshift-stimulatory pseudoknot in SARS-CoV-2 reveals multiple possible conformers

The coronavirus causing the COVID-19 pandemic, SARS-CoV-2, uses −1 programmed ribosomal frameshifting (−1 PRF) to control the relative expression of viral proteins. As modulating −1 PRF can inhibit viral replication, the RNA pseudoknot stimulating −1 PRF may be a fruitful target for therapeutics tre...

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Publicat a:PLoS Comput Biol
Autors principals: Omar, Sara Ibrahim, Zhao, Meng, Sekar, Rohith Vedhthaanth, Moghadam, Sahar Arbabi, Tuszynski, Jack A., Woodside, Michael T.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2021
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7845960/
https://ncbi.nlm.nih.gov/pubmed/33465066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008603
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