Dipeptidyl Peptidase 4 Inhibition for Prophylaxis of Acute Graft-versus-Host Disease

BACKGROUND: Dipeptidyl peptidase 4 (DPP-4; also known as CD26), a transmembrane receptor expressed on T cells, has a costimulatory function in activating T cells. In a mouse model, down-regulation of CD26 prevented graft-versus-host disease (GVHD) but preserved graft-versus-tumor effects. Whether in...

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Bibliografiska uppgifter
I publikationen:N Engl J Med
Huvudupphovsmän: Farag, Sherif S., Zaid, Mohammad Abu, Schwartz, Jennifer E., Thakrar, Teresa C., Blakley, Ann J., Abonour, Rafat, Robertson, Michael J., Broxmeyer, Hal E., Zhang, Shuhong
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2021
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7845486/
https://ncbi.nlm.nih.gov/pubmed/33406328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa2027372
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