High-dose sitagliptin for systemic inhibition of dipeptidylpeptidase-4 to enhance engraftment of single cord umbilical cord blood transplantation

Delayed engraftment remains a limitation of umbilical cord blood (UCB) transplantation. We previously showed that inhibition of dipeptidylpeptidase (DPP)-4 using sitagliptin 600 mg daily was safe with encouraging results on engraftment, but inhibition was not sustained. We evaluated the efficacy and...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Farag, Sherif S., Nelson, Robert, Cairo, Mitchell S., O’Leary, Heather A., Zhang, Shuhong, Huntley, Carol, Delgado, David, Schwartz, Jennifer, Zaid, Mohammad Abu, Abonour, Rafat, Robertson, Michael, Broxmeyer, Hal
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2017
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5746387/
https://ncbi.nlm.nih.gov/pubmed/29299152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22739
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