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Tau-proximity ligation assay reveals extensive previously undetected pathology prior to neurofibrillary tangles in preclinical Alzheimer’s disease
BACKGROUND: Multimerization is a key process in prion-like disorders such as Alzheimer’s disease (AD), since it is a requirement for self-templating tau and beta-amyloid amyloidogenesis. AT8-immunohistochemistry for hyperphosphorylated tau is currently used for the diagnosis and staging of tau patho...
में बचाया:
| में प्रकाशित: | Acta Neuropathol Commun |
|---|---|
| मुख्य लेखकों: | , , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
BioMed Central
2021
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7844979/ https://ncbi.nlm.nih.gov/pubmed/33509301 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-01117-y |
| टैग : |
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