Tau-proximity ligation assay reveals extensive previously undetected pathology prior to neurofibrillary tangles in preclinical Alzheimer’s disease

BACKGROUND: Multimerization is a key process in prion-like disorders such as Alzheimer’s disease (AD), since it is a requirement for self-templating tau and beta-amyloid amyloidogenesis. AT8-immunohistochemistry for hyperphosphorylated tau is currently used for the diagnosis and staging of tau patho...

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Udgivet i:Acta Neuropathol Commun
Main Authors: Bengoa-Vergniory, Nora, Velentza-Almpani, Elisavet, Silva, Ana Maria, Scott, Connor, Vargas-Caballero, Mariana, Sastre, Magdalena, Wade-Martins, Richard, Alegre-Abarrategui, Javier
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7844979/
https://ncbi.nlm.nih.gov/pubmed/33509301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-01117-y
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