Experimental Human Challenge Defines Distinct Pneumococcal Kinetic Profiles and Mucosal Responses between Colonized and Non-Colonized Adults

Colonization of the upper respiratory tract with Streptococcus pneumoniae is the precursor of pneumococcal pneumonia and invasive disease. Following exposure, however, it is unclear which human immune mechanisms determine whether a pathogen will colonize. We used a human challenge model to investiga...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Nikolaou, Elissavet, Jochems, Simon P., Mitsi, Elena, Pojar, Sherin, Blizard, Annie, Reiné, Jesus, Solórzano, Carla, Negera, Edessa, Carniel, Beatriz, Soares-Schanoski, Alessandra, Connor, Victoria, Adler, Hugh, Zaidi, Seher R., Hales, Caz, Hill, Helen, Hyder-Wright, Angie, Gordon, Stephen B., Rylance, Jamie, Ferreira, Daniela M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7844534/
https://ncbi.nlm.nih.gov/pubmed/33436429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02020-20
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