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Biochemical reconstitutions reveal principles of human γ-TuRC assembly and function

The formation of cellular microtubule networks is regulated by the γ-tubulin ring complex (γ-TuRC). This ∼2.3 MD assembly of >31 proteins includes γ-tubulin and GCP2-6, as well as MZT1 and an actin-like protein in a “lumenal bridge” (LB). The challenge of reconstituting the γ-TuRC has limited dis...

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Foilsithe in:J Cell Biol
Main Authors: Wieczorek, Michal, Ti, Shih-Chieh, Urnavicius, Linas, Molloy, Kelly R., Aher, Amol, Chait, Brian T., Kapoor, Tarun M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Rockefeller University Press 2021
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7844428/
https://ncbi.nlm.nih.gov/pubmed/33496729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202009146
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