The T-type calcium channel isoform Ca(v)3.1 is a target for the hypnotic effect of the anaesthetic neurosteroid (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile()

BACKGROUND: The mechanisms underlying the role of T-type calcium channels (T-channels) in thalamocortical excitability and oscillations in vivo during neurosteroid-induced hypnosis are largely unknown. METHODS: We used patch-clamp electrophysiological recordings from acute brain slices ex vivo, reco...

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Detalhes bibliográficos
Publicado no:Br J Anaesth
Main Authors: Timic Stamenic, Tamara, Feseha, Simon, Manzella, Francesca M., Wallace, Damon, Wilkey, Davis, Corrigan, Timothy, Fiedler, Hanna, Doerr, Patricia, Krishnan, Kathiresan, Raol, Yogendra H., Covey, Douglas F., Jevtovic-Todorovic, Vesna, Todorovic, Slobodan M.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
Assuntos:
Neuroscience and Neuroanaesthesia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7844375/
https://ncbi.nlm.nih.gov/pubmed/32859366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bja.2020.07.022
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