A small-molecule P2RX7 activator promotes anti-tumor immune responses and sensitizes lung tumor to immunotherapy

Only a subpopulation of non-small cell lung cancer (NSCLC) patients responds to immunotherapies, highlighting the urgent need to develop therapeutic strategies to improve patient outcome. We develop a chemical positive modulator (HEI3090) of the purinergic P2RX7 receptor that potentiates αPD-1 treat...

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Udgivet i:Nat Commun
Main Authors: Douguet, Laetitia, Janho dit Hreich, Serena, Benzaquen, Jonathan, Seguin, Laetitia, Juhel, Thierry, Dezitter, Xavier, Duranton, Christophe, Ryffel, Bernhard, Kanellopoulos, Jean, Delarasse, Cecile, Renault, Nicolas, Furman, Christophe, Homerin, Germain, Féral, Chloé, Cherfils-Vicini, Julien, Millet, Régis, Adriouch, Sahil, Ghinet, Alina, Hofman, Paul, Vouret-Craviari, Valérie
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7843983/
https://ncbi.nlm.nih.gov/pubmed/33510147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-20912-2
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