Mass Spectrometry Guided Discovery and Design of Novel Asperphenamate Analogs From Penicillium astrolabium Reveals an Extraordinary NRPS Flexibility

Asperphenamate is a small peptide natural product that has gained much interest due to its antitumor activity. In the recent years numerous bioactive synthetic asperphenamate analogs have been reported, whereas only a handful of natural analogs either of microbial or plant origin has been discovered...

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Detalles Bibliográficos
Publicado en:Front Microbiol
Main Authors: Subko, Karolina, Wang, Xinhui, Nielsen, Frederik H., Isbrandt, Thomas, Gotfredsen, Charlotte H., Ramos, Maria C., Mackenzie, Thomas, Vicente, Francisca, Genilloud, Olga, Frisvad, Jens C., Larsen, Thomas O.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2021
Assuntos:
Microbiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7843940/
https://ncbi.nlm.nih.gov/pubmed/33519780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2020.618730
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