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TET-Mediated Epigenetic Regulation in Immune Cell Development and Disease

TET proteins oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and further oxidation products in DNA. The oxidized methylcytosines (oxi-mCs) facilitate DNA demethylation and are also novel epigenetic marks. TET loss-of-function is strongly associated with cancer; TET2 loss-of-function...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Tsiouplis, Nikolas James, Bailey, David Wesley, Chiou, Lilly Felicia, Wissink, Fiona Jane, Tsagaratou, Ageliki
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7843795/
https://ncbi.nlm.nih.gov/pubmed/33520997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.623948
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