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Quantifying the dose-dependent impact of intracellular amyloid beta in a mathematical model of calcium regulation in xenopus oocyte

Alzheimer’s disease (AD) is a devastating illness affecting over 40 million people worldwide. Intraneuronal rise of amyloid beta in its oligomeric forms (iAβOs), has been linked to the pathogenesis of AD by disrupting cytosolic Ca(2+) homeostasis. However, the specific mechanisms of action are still...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:PLoS One
Main Authors: Minicucci, Joseph, Alfond, Molly, Demuro, Angelo, Gerberry, David, Latulippe, Joe
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2021
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7842920/
https://ncbi.nlm.nih.gov/pubmed/33508037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0246116
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