Elevated ABCB1 Expression Confers Acquired Resistance to Aurora Kinase Inhibitor GSK-1070916 in Cancer Cells

The emergence of multidrug resistance (MDR) has been a major issue for effective cancer chemotherapy as well as targeted therapy. One prominent factor that causes MDR is the overexpression of ABCB1 transporter. In the present study, we revealed that the Aurora kinase inhibitor GSK-1070916 is a subst...

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Dades bibliogràfiques
Publicat a:Front Pharmacol
Autors principals: Wu, Zhuo-Xun, Yang, Yuqi, Wang, Jing-Quan, Zhou, Wen-Min, Chen, Junyu, Fu, Yi-Ge, Patel, Ketankumar, Chen, Zhe-Sheng, Zhang, Jian-Ye
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2021
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7841342/
https://ncbi.nlm.nih.gov/pubmed/33519482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.615824
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