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Cyclophosphamide arrhythmogenicitytesting using human-induced pluripotent stem cell-derived cardiomyocytes

Cyclophosphamide (CP) is an anticancer drug, an alkylating agent. Cardiotoxicity of CP is associated with one of its metabolites, acrolein, and clinical cardiotoxicity manifestations are described for cases of taking CP in high doses. Nevertheless, modern arrhythmogenicity prediction assays in vitro...

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Publicat a:Sci Rep
Autors principals: Podgurskaya, A. D., Slotvitsky, M. M., Tsvelaya, V. A., Frolova, S. R., Romanova, S. G., Balashov, V. A., Agladze, K. I.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7841168/
https://ncbi.nlm.nih.gov/pubmed/33504826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-79085-5
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