Anti–Na(+)/K(+)-ATPase immunotherapy ameliorates α-synuclein pathology through activation of Na(+)/K(+)-ATPase α1–dependent autophagy

Na(+)/K(+)-ATPase (NKA) plays important roles in maintaining cellular homeostasis. Conversely, reduced NKA activity has been reported in aging and neurodegenerative diseases. However, little is known about the function of NKA in the pathogenesis of Parkinson’s disease (PD). Here, we report that redu...

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Udgivet i:Sci Adv
Main Authors: Cao, Lei, Xiong, Siping, Wu, Zhiyuan, Ding, Lei, Zhou, Yebo, Sun, Haijian, Zhu, Mengyuan, Lee, Wei Thye, Nie, Xiaowei, Bian, Jin-Song
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2021
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7840131/
https://ncbi.nlm.nih.gov/pubmed/33571110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abc5062
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