Carbomer-based adjuvant elicits CD8 T-cell immunity by inducing a distinct metabolic state in cross-presenting dendritic cells

There is a critical need for adjuvants that can safely elicit potent and durable T cell-based immunity to intracellular pathogens. Here, we report that parenteral vaccination with a carbomer-based adjuvant, Adjuplex (ADJ), stimulated robust CD8 T-cell responses to subunit antigens and afforded effec...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Lee, Woojong, Kingstad-Bakke, Brock, Paulson, Brett, Larsen, Autumn, Overmyer, Katherine, Marinaik, Chandranaik B., Dulli, Kelly, Toy, Randall, Vogel, Gabriela, Mueller, Katherine P., Tweed, Kelsey, Walsh, Alex J., Russell, Jason, Saha, Krishanu, Reyes, Leticia, Skala, Melissa C., Sauer, John-Demian, Shayakhmetov, Dmitry M., Coon, Joshua, Roy, Krishnendu, Suresh, M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7840022/
https://ncbi.nlm.nih.gov/pubmed/33444400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009168
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