Anticancer immunity induced by a synthetic tumor-targeted CD137 agonist

BACKGROUND: In contrast to immune checkpoint inhibitors, the use of antibodies as agonists of immune costimulatory receptors as cancer therapeutics has largely failed. We sought to address this problem using a new class of modular synthetic drugs, termed tumor-targeted immune cell agonists (TICAs),...

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Опубликовано в: :J Immunother Cancer
Главные авторы: Upadhyaya, Punit, Lahdenranta, Johanna, Hurov, Kristen, Battula, Sailaja, Dods, Rachel, Haines, Eric, Kleyman, Marianna, Kristensson, Julia, Kublin, Jessica, Lani, Rachid, Ma, Jun, Mudd, Gemma, Repash, Elizabeth, Van Rietschoten, Katerine, Stephen, Tom, You, Fanglei, Harrison, Helen, Chen, Liuhong, McDonnell, Kevin, Brandish, Philip, Keen, Nicholas
Формат: Artigo
Язык:Inglês
Опубликовано: BMJ Publishing Group 2021
Предметы:
Basic Tumor Immunology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7839861/
https://ncbi.nlm.nih.gov/pubmed/33500260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001762
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