PPARγ increases HUWE1 to attenuate NF-κB/p65 and sickle cell disease with pulmonary hypertension

Sickle cell disease (SCD)-associated pulmonary hypertension (PH) causes significant morbidity and mortality. Here, we defined the role of endothelial specific peroxisome proliferator-activated receptor γ (PPARγ) function and novel PPARγ/HUWE1/miR-98 signaling pathways in the pathogenesis of SCD-PH....

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Jang, Andrew J., Chang, Sarah S., Park, Changwon, Lee, Choon-Myung, Benza, Raymond L., Passineau, Michael J., Ma, Jing, Archer, David R., Sutliff, Roy L., Hart, C. Michael, Kang, Bum-Yong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2021
Assuntos:
Red Cells, Iron, and Erythropoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7839356/
https://ncbi.nlm.nih.gov/pubmed/33496741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020002754
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