Gut CD4(+) T cell phenotypes are a continuum molded by microbes, not by T(H) archetypes.

CD4(+) effector lymphocytes (Teff) are traditionally classified by the cytokines they produce. To determine the states that Teff actually adopt in frontline tissues in vivo, we applied single-cell transcriptome and chromatin analysis on colonic Teff cells, in germ-free or conventional mice, or after...

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Publicado en:Nat Immunol
Autores principales: Kiner, Evgeny, Willie, Elijah, Vijaykumar, Brinda, Chowdhary, Kaitavjeet, Schmutz, Hugo, Chandler, Jodie, Schnell, Alexandra, Thakore, Pratiksha I., LeGros, Graham, Mostafavi, Sara, Mathis, Diane, Benoist, Christophe
Formato: Artigo
Lenguaje:Inglês
Publicado: 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7839314/
https://ncbi.nlm.nih.gov/pubmed/33462454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-020-00836-7
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