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Interleukin 6 produced by enteric neurons regulates the number and phenotype of microbe-responsive regulatory T cells in the gut

The immune and enteric nervous (ENS) systems monitor the frontier with commensal and pathogenic microbes in the colon. We investigated whether FoxP3(+) regulatory T cells (Treg) functionally interact with the ENS. Indeed, microbe-responsive RORγ(+) and Helios(+) subsets localized in close apposition...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Yan, Yiqing, Ramanan, Deepshika, Rozenberg, Milena, McGovern, Kelly, Rastelli, Daniella, Vijaykumar, Brinda, Yaghi, Omar, Voisin, Tiphaine, Mosaheb, Munir, Chiu, Isaac, Itzkovitz, Shalev, Rao, Meenakshi, Mathis, Diane, Benoist, Christophe
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8133394/
https://ncbi.nlm.nih.gov/pubmed/33691135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2021.02.002
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