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Chronic BDNF simultaneously inhibits and unmasks superficial dorsal horn neuronal activity

Brain-derived neurotrophic factor (BDNF) is critically involved in the pathophysiology of chronic pain. However, the mechanisms of BDNF action on specific neuronal populations in the spinal superficial dorsal horn (SDH) requires further study. We used chronic BDNF treatment (200 ng/ml, 5–6 days) of...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Alles, Sascha R. A., Odem, Max A., Lu, Van B., Cassidy, Ryan M., Smith, Peter A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7838274/
https://ncbi.nlm.nih.gov/pubmed/33500423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-81269-6
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