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Chronic BDNF simultaneously inhibits and unmasks superficial dorsal horn neuronal activity

Brain-derived neurotrophic factor (BDNF) is critically involved in the pathophysiology of chronic pain. However, the mechanisms of BDNF action on specific neuronal populations in the spinal superficial dorsal horn (SDH) requires further study. We used chronic BDNF treatment (200 ng/ml, 5–6 days) of...

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Foilsithe in:Sci Rep
Main Authors: Alles, Sascha R. A., Odem, Max A., Lu, Van B., Cassidy, Ryan M., Smith, Peter A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2021
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7838274/
https://ncbi.nlm.nih.gov/pubmed/33500423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-81269-6
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