In vivo silencing of amphiregulin by a novel effective Self-Assembled-Micelle inhibitory RNA ameliorates renal fibrosis via inhibition of EGFR signals

Amphiregulin (AREG) is a transmembrane glycoprotein recently implicated in kidney fibrosis. Previously, we reported that the AREG-targeting Self-Assembled-Micelle inhibitory RNA (SAMiRNA-AREG) alleviated fibrosis by stably silencing the AREG gene, and reduced the side effects of conventional siRNA t...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Son, Seung Seob, Hwang, Soohyun, Park, Jun Hong, Ko, Youngho, Yun, Sung-Il, Lee, Ji-Hye, Son, Beomseok, Kim, Tae Rim, Park, Han-Oh, Lee, Eun Young
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2021
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7838194/
https://ncbi.nlm.nih.gov/pubmed/33500443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-81726-2
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