Single Mutation in the NFU1 Gene Metabolically Reprograms Pulmonary Artery Smooth Muscle Cells

NFU1 is a mitochondrial iron-sulfur scaffold protein, involved in iron-sulfur assembly and transfer to complex II and LAS (lipoic acid synthase). Patients with the point mutation NFU1(G208C) and CRISPR/CAS9 (clustered regularly interspaced short palindromic repeats/clustered regularly interspaced sh...

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Detalhes bibliográficos
Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: James, Joel, Zemskova, Marina, Eccles, Cody A., Varghese, Mathews V., Niihori, Maki, Barker, Natalie K., Luo, Moulun, Mandarino, Lawrence J., Langlais, Paul R., Rafikova, Olga, Rafikov, Ruslan
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2020
Assuntos:
Basic Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7837686/
https://ncbi.nlm.nih.gov/pubmed/33297749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.120.314655
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