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Cardiomyopathic troponin mutations predominantly occur at its interface with actin and tropomyosin
Reversible Ca(2+) binding to troponin is the primary on-off switch of the contractile apparatus of striated muscles, including the heart. Dominant missense mutations in human cardiac troponin genes are among the causes of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy. Structural under...
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| Veröffentlicht in: | J Gen Physiol |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Rockefeller University Press
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7836260/ https://ncbi.nlm.nih.gov/pubmed/33492345 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.202012815 |
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