Deletion of the NKG2C receptor encoding KLRC2 gene and HLA-E variants are risk factors for severe COVID-19

PURPOSE: Host genetic variants may contribute to severity of COVID-19. NKG2C(+) NK cells are potent antiviral effector cells, potentially limiting the extent of SARS-CoV-2 infections. NKG2C is an activating NK cell receptor encoded by the KLRC2 gene, which binds to HLA-E on infected cells leading to...

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Publicado en:Genet Med
Main Authors: Vietzen, Hannes, Zoufaly, Alexander, Traugott, Marianna, Aberle, Judith, Aberle, Stephan W., Puchhammer-Stöckl, Elisabeth
Formato: Artigo
Idioma:Inglês
Publicado: , The Author(s), under exclusive licence to the American College of Medical Genetics and Genomics 2021
Assuntos:
Brief Communication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7835668/
https://ncbi.nlm.nih.gov/pubmed/33500568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41436-020-01077-7
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