Ctcf haploinsufficiency mediates intron retention in a tissue-specific manner

CTCF is a master regulator of gene transcription and chromatin organisation with occupancy at thousands of DNA target sites genome-wide. While CTCF is essential for cell survival, CTCF haploinsufficiency is associated with tumour development and hypermethylation. Increasing evidence demonstrates CTC...

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Bibliografiske detaljer
Udgivet i:RNA Biol
Main Authors: Alharbi, Adel B, Schmitz, Ulf, Marshall, Amy D, Vanichkina, Darya, Nagarajah, Rajini, Vellozzi, Melissa, Wong, Justin JL, Bailey, Charles G, Rasko, John EJ
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2020
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7834090/
https://ncbi.nlm.nih.gov/pubmed/32816606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2020.1796052
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