Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C9 and HLA-B Genotypes and Phenytoin Dosing: 2020 Update

Phenytoin is an antiepileptic drug with a narrow therapeutic index and large inter-patient pharmacokinetic variability, partly due to genetic variation in CYP2C9. Furthermore, the variant allele HLA-B*15:02 is associated with an increased risk of Stevens-Johnson syndrome and toxic epidermal necrolys...

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Udgivet i:Clin Pharmacol Ther
Main Authors: Karnes, Jason H., Rettie, Allan E., Somogyi, Andrew A., Huddart, Rachel, Fohner, Alison E., Formea, Christine M., Michael Lee, Ming Ta, Llerena, Adrian, Whirl-Carrillo, Michelle, Klein, Teri E., Phillips, Elizabeth J., Mintzer, Scott, Gaedigk, Andrea, Caudle, Kelly E., Callaghan, John T.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7831382/
https://ncbi.nlm.nih.gov/pubmed/32779747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.2008
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