Activity of murine surrogate antibodies for durvalumab and tremelimumab lacking effector function and the ability to deplete regulatory T cells in mouse models of cancer

Preclinical studies of PD-L1 and CTLA-4 blockade have relied heavily on mouse syngeneic tumor models with intact immune systems, which facilitate dissection of immunosuppressive mechanisms in the tumor microenvironment. Commercially developed monoclonal antibodies (mAbs) targeting human PD-L1, PD-1,...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:MAbs
Hoofdauteurs: Schofield, Darren J., Percival-Alwyn, Jennifer, Rytelewski, Mateusz, Hood, John, Rothstein, Raymond, Wetzel, Leslie, McGlinchey, Kelly, Adjei, Grace, Watkins, Amanda, Machiesky, LeeAnn, Chen, Weimin, Andrews, John, Groves, Maria, Morrow, Michelle, Stewart, Ross A., Leinster, Andrew, Wilkinson, Robert W., Hammond, Scott A., Luheshi, Nadia, Dobson, Claire, Oberst, Michael
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis 2021
Onderwerpen:
Report
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7831362/
https://ncbi.nlm.nih.gov/pubmed/33397194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2020.1857100
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items