CAR T cells in solid tumors: challenges and opportunities

BACKGROUND: CARs are simulated receptors containing an extracellular single-chain variable fragment (scFv), a transmembrane domain, as well as an intracellular region of immunoreceptor tyrosine-based activation motifs (ITAMs) in association with a co-stimulatory signal. MAIN BODY: Chimeric antigen r...

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Библиографические подробности
Опубликовано в: :Stem Cell Res Ther
Главные авторы: Marofi, Faroogh, Motavalli, Roza, Safonov, Vladimir A., Thangavelu, Lakshmi, Yumashev, Alexei Valerievich, Alexander, Markov, Shomali, Navid, Chartrand, Max Stanley, Pathak, Yashwant, Jarahian, Mostafa, Izadi, Sepideh, Hassanzadeh, Ali, Shirafkan, Naghmeh, Tahmasebi, Safa, Khiavi, Farhad Motavalli
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2021
Предметы:
Review
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7831265/
https://ncbi.nlm.nih.gov/pubmed/33494834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-020-02128-1
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