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Targeting E-selectin to Tackle Cancer Using Uproleselan
SIMPLE SUMMARY: This review focuses on eradicating cancer by targeting a surface protein expressed on the endothelium—E-selectin—with a novel drug, uproleselan (GMI-1271). Blocking E-selectin in the tumor microenvironment acts on multiple levels; uproleselan was shown (i) to inhibit cancer cell teth...
Gespeichert in:
| Veröffentlicht in: | Cancers (Basel) |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
MDPI
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7831123/ https://ncbi.nlm.nih.gov/pubmed/33477563 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13020335 |
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