Chemopreventive Effect of 5-Flurouracil Polymeric Hybrid PLGA-Lecithin Nanoparticles against Colon Dysplasia Model in Mice and Impact on p53 Apoptosis

The use of 5-fluorouracil (5FU) is associated with multifaceted challenges and poor pharmacokinetics. Poly(lactic-co-glycolic acid)-lipid hybrid nanoparticles (PLNs)-based therapy has received attention as efficient carriers for a diversity of drugs. This study evaluated the in vivo chemotherapeutic...

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Detalhes bibliográficos
Publicado no:Biomolecules
Main Authors: A. Attia, Mohammed, Enan, Eman T., Hashish, Abdullah A., M. H. El-kannishy, Sherif, Gardouh, Ahmed R., K. Tawfik, Mona, Faisal, Salwa, El-Mistekawy, Amr, Salama, Ayman, Alomar, Suliman Y., H. Eltrawy, Amira, Yagub Aloyouni, Sheka, Zaitone, Sawsan A.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7830948/
https://ncbi.nlm.nih.gov/pubmed/33467560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom11010109
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