Lactate Limits T Cell Proliferation via the NAD(H) Redox State

Immune cell function is influenced by metabolic conditions. Low-glucose, high-lactate environments, such as the placenta, gastrointestinal tract, and the tumor microenvironment, are immunosuppressive, especially for glycolysis-dependent effector T cells. We report that nicotinamide adenine dinucleot...

詳細記述

保存先:
書誌詳細
出版年:Cell Rep
主要な著者: Quinn, William J., Jiao, Jing, TeSlaa, Tara, Stadanlick, Jason, Wang, Zhonglin, Wang, Liqing, Akimova, Tatiana, Angelin, Alessia, Schäfer, Patrick M., Cully, Michelle D., Perry, Caroline, Kopinski, Piotr K., Guo, Lili, Blair, Ian A., Ghanem, Louis R., Leibowitz, Michael S., Hancock, Wayne W., Moon, Edmund K., Levine, Matthew H., Eruslanov, Evgeniy B., Wallace, Douglas C., Baur, Joseph A., Beier, Ulf H.
フォーマット: Artigo
言語:Inglês
出版事項: 2020
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7830708/
https://ncbi.nlm.nih.gov/pubmed/33326785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108500
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