Empagliflozin Attenuates Non-Alcoholic Fatty Liver Disease (NAFLD) in High Fat Diet Fed ApoE((-/-)) Mice by Activating Autophagy and Reducing ER Stress and Apoptosis

Aims/hypothesis: SGLT-2 inhibitors (SGLT-2i) have been studied as potential treatments against NAFLD, showing varying beneficial effects. The molecular mechanisms mediating these effects have not been fully clarified. Herein, we investigated the impact of empagliflozin on NAFLD, focusing particularl...

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Publicat a:Int J Mol Sci
Autors principals: Nasiri-Ansari, Narjes, Nikolopoulou, Chrysa, Papoutsi, Katerina, Kyrou, Ioannis, Mantzoros, Christos S., Kyriakopoulos, Georgios, Chatzigeorgiou, Antonios, Kalotychou, Vassiliki, Randeva, Manpal S., Chatha, Kamaljit, Kontzoglou, Konstantinos, Kaltsas, Gregory, Papavassiliou, Athanasios G., Randeva, Harpal S., Kassi, Eva
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7829901/
https://ncbi.nlm.nih.gov/pubmed/33467546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22020818
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