Empagliflozin Attenuates Non-Alcoholic Fatty Liver Disease (NAFLD) in High Fat Diet Fed ApoE((-/-)) Mice by Activating Autophagy and Reducing ER Stress and Apoptosis

Aims/hypothesis: SGLT-2 inhibitors (SGLT-2i) have been studied as potential treatments against NAFLD, showing varying beneficial effects. The molecular mechanisms mediating these effects have not been fully clarified. Herein, we investigated the impact of empagliflozin on NAFLD, focusing particularl...

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Bibliografski detalji
Izdano u:Int J Mol Sci
Glavni autori: Nasiri-Ansari, Narjes, Nikolopoulou, Chrysa, Papoutsi, Katerina, Kyrou, Ioannis, Mantzoros, Christos S., Kyriakopoulos, Georgios, Chatzigeorgiou, Antonios, Kalotychou, Vassiliki, Randeva, Manpal S., Chatha, Kamaljit, Kontzoglou, Konstantinos, Kaltsas, Gregory, Papavassiliou, Athanasios G., Randeva, Harpal S., Kassi, Eva
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2021
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7829901/
https://ncbi.nlm.nih.gov/pubmed/33467546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22020818
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