Optimization of 1,4-Naphthoquinone Hit Compound: A Computational, Phenotypic, and In Vivo Screening against Trypanosoma cruzi

Chagas disease (CD) still represents a serious public health problem in Latin America, even after more than 100 years of its discovery. Clinical treatments (nifurtimox and benznidazole) are considered inadequate, especially because of undesirable side effects and low efficacy in the chronic stages o...

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Veröffentlicht in:Molecules
Hauptverfasser: Lara, Leonardo S., Lechuga, Guilherme C., Moreira, Caroline dos S., Santos, Thaís B., Ferreira, Vitor F., da Rocha, David R., Pereira, Mirian C. S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7829778/
https://ncbi.nlm.nih.gov/pubmed/33467422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26020423
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