Twist-1 is upregulated by NSD2 and contributes to tumour dissemination and an epithelial-mesenchymal transition-like gene expression signature in t(4;14)-positive multiple myeloma

Approximately 15% of patients with multiple myeloma (MM) harbour the t(4;14) chromosomal translocation, leading to the overexpression of the histone methyltransferase NSD2. Patients with this translocation display increased tumour dissemination, accelerated disease progression and rapid relapse. Usi...

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Detalhes bibliográficos
Publicado no:Cancer Lett
Main Authors: Cheong, Chee Man, Mrozik, Krzysztof M., Hewett, Duncan R., Bell, Elyse, Panagopoulos, Vasilios, Noll, Jacqueline E., Licht, Jonathan D., Gronthos, Stan, Zannettino, Andrew C.W., Vandyke, Kate
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7829063/
https://ncbi.nlm.nih.gov/pubmed/32014459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2020.01.040
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