Altered ratio of dendritic cell subsets in skin-draining lymph nodes promotes Th2-driven contact hypersensitivity

Plasmacytoid dendritic cells (pDCs) specialize in the production of type I IFN (IFN-I). pDCs can be depleted in vivo by injecting diphtheria toxin (DT) in a mouse in which pDCs express a diphtheria toxin receptor (DTR) transgene driven by the human CLEC4C promoter. This promoter is enriched for bind...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Miller, Hannah L., Andhey, Prabhakar Sairam, Swiecki, Melissa K., Rosa, Bruce A., Zaitsev, Konstantin, Villani, Alexandra-Chloe, Mitreva, Makedonka, Artyomov, Maxim N., Gilfillan, Susan, Cella, Marina, Colonna, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7826349/
https://ncbi.nlm.nih.gov/pubmed/33431694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2021364118
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