Φορτώνει......
Negative selection on human genes underlying inborn errors depends on disease outcome and both the mode and mechanism of inheritance
Genetic variants underlying life-threatening diseases, being unlikely to be transmitted to the next generation, are gradually and selectively eliminated from the population through negative selection. We study the determinants of this evolutionary process in human genes underlying monogenic diseases...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Proc Natl Acad Sci U S A |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
National Academy of Sciences
2021
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7826345/ https://ncbi.nlm.nih.gov/pubmed/33408250 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2001248118 |
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