Conformational constraints of cyclopentane peptide nucleic acids facilitate tunable binding to DNA

We report a series of synthetic, nucleic acid mimics with highly customizable thermodynamic binding to DNA. Incorporation of helix-promoting cyclopentanes into peptide nucleic acids (PNAs) increases the melting temperatures (T(m)) of PNA+DNA duplexes by approximately +5°C per cyclopentane. Sequentia...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Zheng, Hongchao, Botos, Istvan, Clausse, Victor, Nikolayevskiy, Herman, Rastede, Elizabeth E, Fouz, Munira F, Mazur, Sharlyn J, Appella, Daniel H
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2021
Fag:
Chemical Biology and Nucleic Acid Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7826248/
https://ncbi.nlm.nih.gov/pubmed/33406227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1249
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