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Conformational constraints of cyclopentane peptide nucleic acids facilitate tunable binding to DNA
We report a series of synthetic, nucleic acid mimics with highly customizable thermodynamic binding to DNA. Incorporation of helix-promoting cyclopentanes into peptide nucleic acids (PNAs) increases the melting temperatures (T(m)) of PNA+DNA duplexes by approximately +5°C per cyclopentane. Sequentia...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7826248/ https://ncbi.nlm.nih.gov/pubmed/33406227 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1249 |
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