CSN6 promotes melanoma proliferation and metastasis by controlling the UBR5-mediated ubiquitination and degradation of CDK9

As a critical subunit of the constitutive photomorphogenesis 9 (COP9) signalosome (CSN), CSN6 is upregulated in some human cancers and plays critical roles in tumorigenesis and progression, but its biological functions and molecular mechanisms in melanoma remain unknown. Our study showed that CSN6 e...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Death Dis
Egile Nagusiak: Zhang, Yanli, Hou, Jianbing, Shi, Shaomin, Du, Juan, Liu, Yudong, Huang, Pan, Li, Qian, Liu, Lichao, Hu, Huanrong, Ji, Yacong, Guo, Leiyang, Shi, Yaqiong, Liu, Yaling, Cui, Hongjuan
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2021
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7822921/
https://ncbi.nlm.nih.gov/pubmed/33483464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03398-0
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