Inactivation/deficiency of DHODH induces cell cycle arrest and programed cell death in melanoma

Malignant melanoma (MM) is one of the most malignant tumors and has a very poor prognosis. However, there are no effective drugs to treat this disease. As a kind of iron flavin dependent enzyme, dihydroorotate dehydrogenase (DHODH, EC 1.3.3.1) is the fourth and a key enzyme in the de novo biosynthes...

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Detalhes bibliográficos
Publicado no:Oncotarget
Principais autores: Liu, Lichao, Dong, Zhen, Lei, Qian, Yang, Jie, Hu, Huanrong, Li, Qian, Ji, Yacong, Guo, Leiyang, Zhang, Yanli, Liu, Yaling, Cui, Hongjuan
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5762515/
https://ncbi.nlm.nih.gov/pubmed/29348830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19379
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