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Inactivation/deficiency of DHODH induces cell cycle arrest and programed cell death in melanoma
Malignant melanoma (MM) is one of the most malignant tumors and has a very poor prognosis. However, there are no effective drugs to treat this disease. As a kind of iron flavin dependent enzyme, dihydroorotate dehydrogenase (DHODH, EC 1.3.3.1) is the fourth and a key enzyme in the de novo biosynthes...
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| Publicado no: | Oncotarget |
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| Principais autores: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5762515/ https://ncbi.nlm.nih.gov/pubmed/29348830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19379 |
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