Artemisinin-resistant K13 mutations rewire Plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival

The emergence and spread of artemisinin resistance, driven by mutations in Plasmodium falciparum K13, has compromised antimalarial efficacy and threatens the global malaria elimination campaign. By applying systems-based quantitative transcriptomics, proteomics, and metabolomics to a panel of isogen...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Mok, Sachel, Stokes, Barbara H., Gnädig, Nina F., Ross, Leila S., Yeo, Tomas, Amaratunga, Chanaki, Allman, Erik, Solyakov, Lev, Bottrill, Andrew R., Tripathi, Jaishree, Fairhurst, Rick M., Llinás, Manuel, Bozdech, Zbynek, Tobin, Andrew B., Fidock, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7822823/
https://ncbi.nlm.nih.gov/pubmed/33483501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20805-w
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