Microbial Lipid A Remodeling Controls Cross-Presentation Efficiency and CD8 T Cell Priming by Modulating Dendritic Cell Function

The majority of Gram-negative bacteria elicit a potent immune response via recognition of lipid A expressed on the outer bacterial membrane by the host immune receptor Toll-like receptor 4 (TLR4). However, some Gram-negative bacteria evade detection by TLR4 or alter the outcome of TLR4 signaling by...

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Bibliographische Detailangaben
Veröffentlicht in:Infect Immun
Hauptverfasser: Papadopoulos, George, Berland, Robert, Sunkavalli, Ashwini, Coats, Stephen R., Darveau, Richard P., Genco, Caroline A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2021
Schlagworte:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7822130/
https://ncbi.nlm.nih.gov/pubmed/33257533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00335-20
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